This paper deals with families from Slano in the Spanish service. In the introduction, the general geopolitical situation of the Republic of Dubrovnik is stated and its relationship with Spain is explained. The official relationship of the Dubrovnik authorities towards the Spanish Habsburg rulers and the entry of individual Dubrovnik citizens into the Spanish service are observed. A special focus is on the people of Slano, showing the economic and social rise of the Slano families during the 16th century and their accession to the Spanish service. It shows the birth-native circle of the Slano families and the attempt to realize their social aspirations within the framework of the Spanish service. The family of Ohmućević is observed and their naval and military exploits in the service of the Spanish crown are shown. Captain Petar Ohmućević is highlighted and his striving for social progress in the form of noble status achieved under the patronage of the Spanish and Neapolitan courts is analyzed. For this purpose, the Ohmućević create a falsified genealogy, portraying themselves as ancient Bosnian nobility. The family of Dolisti-Tasovčić is also mentioned, which is characterized by the same social and economic aspirations, and Stjepan Dolisti-Tasovčić stands out in the Spanish service. He participated in the Invincible Armada venture in 1588 and continued to serve the Spanish crown alongside his mentor and uncle Petar Ohmućević. The paper also deals with the Korjenić-Neorić family, showing their service in the Spanish court and analyzing the enriched family genealogy that culminates in the Korjenić-Neorić armorial. The paper also deals with the people of Slano in the Spanish service during the 17th century, where the second branch of the Ohmućević family stands out. Also, the people of Slano are seen as participants in anti-Turkish conspiracies in the Balkans at the expense of the Spanish and other Christian rulers.