This paper presents the history of the region of Trilj in the period of the early modern age, actually the period from the end of the Middle Ages, the Ottoman era and the period of Venetian rule in these areas. In the first part of the paper, a brief history of the Trilj region is presented, and a detailed description of historical events begins with the reign of the Dražojević princes. . With the fall of Herzegovina to the Turks, the door to the Cetinje region was open, so the important Trillian fortress of Čačvina fell under Ottoman rule as early as 1513, thus beginning the Ottoman administration of this area. In the midst of the VenetianTurkish wars, Christians from Herzegovina and Poljica began to immigrate to the Trilj area, and the period after 1690 until the Little or Sinj War is taken as the key period of migration. During the period of Venetian administration over the Trilj area, trade and agriculture improved, but the rise was greatly slowed down by the appearance of the plague, which ravaged Dalmatia and Herzegovina on several occasion.