This study investigates the relationship between various categories of online game content and their association with players' self-esteem and well-being, with a particular focus on players of League of Legends (LoL) due to high prevalence of participants playing it. The research aimed to explore whether different game genres, including cooperative, competitive, educational, and violent games, correlate with players' self-esteem and well-being. A cross-sectional design was employed using an online survey distributed to a geographically diverse sample. Descriptive statistics and the Kruskal-Wallis test in statistical software JASP were utilized to analyze differences across game content categories. Results indicated no significant association between any game content type and players' self-esteem or well-being. However, a notable exception was observed among League of Legends players, who displayed a negative association with both self-esteem and well-being compared to players of other game genres. This negative association may be further explored through Social Identity Theory, which examines how group affiliations and competitive dynamics influence self-perception and emotional outcomes, or through the specific competitive aspects inherent in the game. The study also highlighted that these players reported lower levels of well-being and self-esteem, suggesting that the highly competitive environment and the effort and financial resources invested in personalization might be contributing factors to this association. Future research should delve deeper into the motivations behind players' engagement with different game types and investigate the broader mental health implications of competitive gaming environments. Additionally, a longitudinal approach could provide more insights into how these dynamics evolve over time.